Zenutri Antioxidant Essentials Bundle

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Antioxidant Essentials Bundle | Broad-Spectrum Cellular Protection | Zenutri Australia
TGA-Certified • Clinically Validated • Australian Made

Antioxidant Essentials Bundle

Two-Formula Cellular Protection System

2 Synergistic Formulas
6 Antioxidant Pathways
30 Day Supply
100% Evidence-Based
Vitamin C • Vitamin E • Curcumin • Resveratrol

Comprehensive antioxidant defense combining vitamins C, E, and B3 with curcumin and resveratrol for broad-spectrum cellular protection. Clinical-dose nutrients supporting redox balance, healthy inflammatory responses, and immune function through pharmaceutical-grade, TGA-certified formulations that reduce free radical damage and maintain cellular integrity across all compartments—providing water-soluble, fat-soluble, and polyphenolic antioxidant coverage for complete oxidative stress defense and long-term cellular health.

Antioxidant Synergy Mechanisms

Vitamin C + Vitamin E: Regenerating Antioxidant Network

Synergistic water-soluble and fat-soluble protection across all cellular compartments

Vitamin C (calcium ascorbate) provides water-soluble antioxidant protection in cytoplasm and extracellular fluids, while vitamin E (mixed tocopherols) protects lipid-rich environments including cell membranes and lipoproteins. Critically, vitamin C regenerates oxidized vitamin E, creating a self-sustaining antioxidant network. This synergy provides comprehensive cellular protection—vitamin C prevents lipid peroxidation initiation while vitamin E prevents propagation. Together, they reduce oxidative stress biomarkers more effectively than either antioxidant alone, supporting cellular integrity across all compartments.

Curcumin + BioPerine: Maximum Anti-Inflammatory & Antioxidant Action

2000% bioavailability enhancement for therapeutic blood levels

Curcumin provides potent antioxidant and anti-inflammatory effects by suppressing NF-κB activation and scavenging reactive oxygen species. However, poor bioavailability limits effectiveness. BioPerine (standardized piperine) inhibits glucuronidation enzymes, increasing curcumin absorption by up to 2000%. This dramatic enhancement ensures therapeutic blood levels, making curcumin clinically effective for reducing oxidative stress, supporting healthy inflammatory responses, and providing cellular protection. Without BioPerine, most curcumin is metabolized before reaching systemic circulation.

Resveratrol + Curcumin: Polyphenol Cellular Defense

Dual activation of endogenous antioxidant pathways through Nrf2

Resveratrol and curcumin both activate Nrf2 (nuclear factor erythroid 2-related factor 2), the master regulator of cellular antioxidant defense. Nrf2 activation upregulates phase II detoxification enzymes, glutathione synthesis, and antioxidant proteins including superoxide dismutase (SOD) and catalase. This means these polyphenols don't just provide direct antioxidant action—they enhance your body's own antioxidant production. Combined, they provide synergistic Nrf2 activation, supporting long-term cellular resilience against oxidative stress. BioPerine enhances absorption of both polyphenols.

Nicotinamide + B-Complex: NAD+ & Glutathione Support

Essential cofactors supporting cellular redox systems and antioxidant regeneration

Nicotinamide (vitamin B3) is a direct precursor to NAD+/NADH and NADP+/NADPH—the redox couples essential for cellular energy metabolism and antioxidant defense. NADPH specifically drives glutathione reductase, regenerating reduced glutathione—the most abundant intracellular antioxidant. B-complex vitamins (B1, B2, B6, folate, B12, biotin) support NADPH production through the pentose phosphate pathway and maintain glutathione synthesis. Together, they ensure the cellular machinery supporting antioxidant systems functions optimally, providing foundational redox support.

Vitamin E + Resveratrol: Lipid Peroxidation Defense

Dual protection against oxidative damage to cellular membranes and lipoproteins

Vitamin E (particularly gamma-tocopherol in mixed tocopherol formulations) is the primary defense against lipid peroxidation in cell membranes and LDL cholesterol. Resveratrol complements this protection by reducing oxidative stress and supporting cardiovascular health through multiple mechanisms including enhanced nitric oxide bioavailability. Together, they provide comprehensive protection for lipid-rich tissues and lipoproteins, supporting cardiovascular health, cellular membrane integrity, and protection against age-related oxidative damage to lipid structures.

Complete Spectrum Coverage: Water, Lipid & Polyphenolic

Comprehensive antioxidant protection across all cellular compartments and tissue types

This bundle delivers true broad-spectrum antioxidant coverage: vitamin C protects aqueous environments (cytoplasm, blood, extracellular fluid), vitamin E protects lipid environments (membranes, lipoproteins), and polyphenols (curcumin, resveratrol) provide both compartment-specific protection and Nrf2-mediated enhancement of endogenous antioxidant systems. This three-pronged approach ensures no cellular compartment is left vulnerable to oxidative stress. Combined with B-vitamins supporting redox cofactor production, this represents comprehensive, multi-layered antioxidant defense for optimal cellular health and longevity.

Six Pathways to Cellular Protection

Broad-Spectrum Antioxidant Defense
Vitamin C (250mg), vitamin E (70mg), curcumin, and resveratrol provide comprehensive coverage across water-soluble, fat-soluble, and polyphenolic antioxidant categories
Free Radical Neutralization
Direct scavenging of reactive oxygen species (ROS) including superoxide, hydroxyl radicals, and lipid peroxides protecting DNA, proteins, and lipids from oxidative damage
Cellular Redox Balance
Nicotinamide (125mg) and B-complex vitamins support NAD+/NADPH production, glutathione recycling, and redox homeostasis essential for cellular function
Inflammatory Balance Support
Curcumin and resveratrol suppress NF-κB activation and reduce inflammatory cytokines, supporting healthy inflammatory responses without suppressing normal immune function
Endogenous Antioxidant Activation
Polyphenols activate Nrf2 pathways, upregulating phase II detoxification enzymes, glutathione synthesis, and antioxidant proteins for long-term cellular resilience
Enhanced Bioavailability System
BioPerine (15mg) increases curcumin and resveratrol absorption by up to 2000%, ensuring therapeutic blood levels and maximum antioxidant effectiveness
Clinical Evidence & Research Foundation

The Science Behind Antioxidant Essentials

Every ingredient is supported by peer-reviewed research demonstrating antioxidant and cellular protection benefits

Vitamin C & E: Synergistic Antioxidant Protection
Combined vitamin C and E supplementation provides superior antioxidant protection compared to single antioxidants. Vitamin C regenerates oxidized vitamin E, creating a self-sustaining antioxidant network. Meta-analyses of randomized controlled trials demonstrate combined C+E supplementation significantly reduces biomarkers of oxidative stress (malondialdehyde, F2-isoprostanes) and increases total antioxidant capacity. Our formula provides 250mg vitamin C as calcium ascorbate (non-acidic) and 70mg mixed tocopherols (superior to alpha-tocopherol alone) for comprehensive cellular protection.
Huang et al., Nutr Rev 2018 | Carr & Frei, Am J Clin Nutr 1999 | Bruno et al., Free Radic Res 2006
Curcumin: Multi-Mechanism Antioxidant & Anti-Inflammatory
Curcumin provides potent antioxidant activity through direct free radical scavenging and by activating Nrf2-dependent antioxidant pathways. Umbrella meta-analyses of randomized controlled trials show curcumin supplementation significantly reduces inflammatory markers (CRP, IL-6, TNF-α) by 30-60%. Curcumin also increases endogenous antioxidant enzymes including glutathione peroxidase and superoxide dismutase. The primary limitation is poor bioavailability—addressed in our formula through BioPerine enhancement. Our 100mg dose with BioPerine achieves therapeutic blood levels validated in clinical research.
Hewlings & Kalman, Foods 2017 | Sahebkar et al., Biomed Pharmacother 2015 | Aggarwal et al., Biochem Pharmacol 2017
Resveratrol: Polyphenolic Antioxidant & SIRT1 Activator
Resveratrol is a stilbene polyphenol with multiple mechanisms supporting cellular health including direct antioxidant activity, Nrf2 activation, and SIRT1 pathway modulation. Clinical trials demonstrate resveratrol supplementation (100-300mg daily) reduces oxidative stress biomarkers, improves endothelial function, and supports cardiovascular health. Resveratrol protects against lipid peroxidation and enhances nitric oxide bioavailability. Our 150mg dose combined with curcumin provides synergistic polyphenol protection, with BioPerine enhancing absorption of both compounds.
Tomé-Carneiro et al., Ann N Y Acad Sci 2013 | Gliemann et al., Nutrients 2013 | Bo et al., Int J Mol Sci 2013
Nicotinamide & B-Complex: Redox Cofactor Support
Nicotinamide (vitamin B3) is essential for NAD+ biosynthesis—the redox cofactor driving cellular energy metabolism and antioxidant defense. NADPH derived from NAD+ powers glutathione reductase, maintaining reduced glutathione—the most abundant intracellular antioxidant. B-complex vitamins (B1, B2, B6, folate, B12, biotin) support NADPH production through the pentose phosphate pathway. Our formula provides 125mg nicotinamide plus comprehensive B-complex to ensure optimal redox cofactor availability, supporting both direct antioxidant action and cellular antioxidant enzyme function.
Poljsak & Milisav, Oxid Med Cell Longev 2016 | Imai & Guarente, Trends Cell Biol 2014 | Kennedy, Nutrients 2016
BioPerine: Bioavailability Enhancement Technology
BioPerine is a standardized extract from black pepper (Piper nigrum) containing 95% piperine. The landmark study by Shoba et al. demonstrated piperine increases curcumin bioavailability by 2000% in humans by inhibiting glucuronidation—the primary metabolic pathway for curcumin elimination. BioPerine also enhances resveratrol absorption by inhibiting efflux transporters and phase II enzymes. Without bioavailability enhancement, oral curcumin and resveratrol achieve minimal systemic exposure. BioPerine inclusion is essential for clinical effectiveness, transforming theoretically beneficial compounds into therapeutically active nutrients.
Shoba et al., Planta Med 1998 (PMID: 9619120) | Johnson et al., J Agric Food Chem 2011 | Dudhatra et al., J Appl Pharm Sci 2012
Nrf2 Activation: Endogenous Antioxidant Enhancement
Nrf2 (nuclear factor erythroid 2-related factor 2) is the master regulator of cellular antioxidant defense. Activation of Nrf2 by polyphenols including curcumin and resveratrol upregulates phase II detoxification enzymes (glutathione S-transferase, NAD(P)H:quinone oxidoreductase), glutathione synthesis enzymes, and antioxidant proteins (superoxide dismutase, catalase, glutathione peroxidase). This means polyphenols don't just provide direct antioxidant action—they enhance the body's own antioxidant production. Combined curcumin and resveratrol provide synergistic Nrf2 activation for sustained cellular protection.
Kelkel et al., Biochem Pharmacol 2010 | Hybertson et al., Antioxidants 2011 | Raghunath et al., Food Funct 2013

The Antioxidant Essentials Formula

Two precision-dosed TGA-certified supplements delivering comprehensive antioxidant protection

AUST L 521487

Zenutri C E B Optima

Vitamin C (Calcium Ascorbate)

250mg per capsule

Vitamin E (Mixed Tocopherols)

70mg per capsule

Nicotinamide (Vitamin B3)

125mg per capsule

Water & fat-soluble antioxidant protection, redox cofactor support, cellular defense, immune function

1 capsule daily with any meal

AUST L 520796

Zenutri CurcuNova

Curcuma longa extract

100mg (equiv. 2g dry rhizome)

Resveratrol

150mg per capsule

BioPerine® (Piper nigrum)

15mg equivalent

B-Complex Vitamins

Complete spectrum included

Polyphenolic antioxidant support, anti-inflammatory action, Nrf2 activation, enhanced bioavailability, cardiovascular wellness

1 capsule daily with meal containing healthy fats

Progressive Cellular Protection Timeline

Experience measurable improvements in antioxidant defense and cellular health with consistent use

Weeks 1-4
Months 1-3
3+ Months
Early Phase: Immediate Antioxidant Protection (1-4 Weeks)
  • Direct Free Radical Scavenging: Vitamins C and E begin neutralizing reactive oxygen species immediately upon absorption, reducing oxidative stress
  • Increased Antioxidant Capacity: Total antioxidant capacity rises as water-soluble, fat-soluble, and polyphenolic antioxidants establish comprehensive cellular protection
  • Reduced Oxidative Stress Biomarkers: Measurable decreases in lipid peroxidation products and oxidative damage markers within 2-4 weeks
  • Enhanced BioPerine Absorption: Curcumin and resveratrol achieve therapeutic blood levels with 2000% enhanced bioavailability
  • Initial Nrf2 Activation: Polyphenols begin upregulating endogenous antioxidant enzyme expression
Intermediate Phase: Cellular Defense Optimization (1-3 Months)
  • Upregulated Endogenous Antioxidants: Nrf2-mediated increases in glutathione, superoxide dismutase, and catalase providing sustained cellular protection
  • Reduced Inflammatory Markers: Significant decreases in CRP, IL-6, and TNF-α supporting healthy inflammatory balance throughout the body
  • Enhanced Cellular Resilience: Improved cellular stress resistance and adaptation to oxidative challenges from environmental, metabolic, or lifestyle factors
  • Cardiovascular Function Support: Improved endothelial function, enhanced nitric oxide bioavailability, and reduced oxidative stress in vascular tissues
  • Immune System Support: Optimized immune cell function supported by adequate vitamin C, E, and B-vitamins
  • Protected Cellular Structures: Reduced oxidative damage to DNA, proteins, and lipid membranes supporting cellular integrity
Long-Term Phase: Sustained Cellular Health & Protection (3+ Months)
  • Maintained Redox Homeostasis: Stable cellular redox balance supporting optimal cellular function and metabolic health
  • Long-Term Cellular Protection: Continuous defense against oxidative stress protecting against age-related cellular damage and supporting healthy aging
  • Enhanced Detoxification: Upregulated phase II enzymes supporting efficient elimination of oxidative metabolites and environmental toxins
  • Cardiovascular Health Maintenance: Sustained endothelial health, vascular function, and protection against oxidative LDL modification
  • Cognitive Function Support: Reduced oxidative stress in neural tissues supporting cognitive health and neuroprotection
  • Immune System Optimization: Maintained immune function and balanced inflammatory responses supporting overall health
  • Comprehensive Wellness: Multi-system benefits from sustained antioxidant protection including improved energy, stress resilience, and overall vitality

Clinical Usage Protocol

Evidence-based dosing schedule for maximum antioxidant protection and cellular health

1

Morning: Foundation Antioxidants

Zenutri C E B Optima: Take 1 capsule with breakfast or any meal. Vitamin C is water-soluble and doesn't require fat for absorption, while vitamin E absorption is enhanced with dietary fat. Morning dosing supports daytime antioxidant protection.

Timing rationale: Morning administration provides antioxidant coverage during waking hours when oxidative stress from physical activity, environmental exposure, and metabolism is highest.

2

With Fat: Polyphenol Enhancement

Zenutri CurcuNova: Take 1 capsule with a meal containing healthy fats (15-20g). Both curcumin and resveratrol are lipophilic and absorption significantly improves with dietary fat. Ideal meal companions: eggs, avocado, nuts, olive oil, fatty fish.

Timing rationale: Fat enhances polyphenol absorption even with BioPerine. Can be taken with same breakfast as C E B Optima if meal contains adequate fat, or with lunch/dinner.

Optimization Tips

  • Consistency is critical: Take at the same times daily to maintain stable antioxidant coverage and optimize cellular protection
  • With healthy fats: Always take CurcuNova with meals containing 15-20g healthy fats for optimal curcumin and resveratrol absorption
  • Timeline: Allow 4-8 weeks for full antioxidant benefits—Nrf2 upregulation and cellular adaptation take time
  • Lifestyle synergy: Combine with antioxidant-rich diet (colorful fruits/vegetables), regular exercise, adequate sleep, and stress management
  • Avoid mega-dosing: More is not better—these doses are optimized for safety and effectiveness based on clinical research
  • Hydration: Take supplements with a full glass of water (250-300ml) to support absorption and cellular function

Pharmaceutical-Grade Quality Standards

TGA Listed Medicines
cGMP Certified
Third-Party Verified
Australian Made

Rigorous Quality & Safety Protocols

  • TGA Listed Medicines: Both formulations are individually listed with the Therapeutic Goods Administration (AUST L 521487, 520796), meeting Australia's stringent pharmaceutical quality standards. Start date: 25/11/2025.
  • Current Good Manufacturing Practice: Produced in TGA-licensed cGMP facilities including BJP Laboratories, CGS Pharma, Complementary Medicines Group, Lavida Nutraceuticals, and Lipa Pharmaceuticals—all with validated manufacturing processes and full batch traceability
  • Independent Laboratory Testing: Third-party verification by accredited Australian laboratories confirms identity, purity, potency, and absence of contaminants including heavy metals, microbiological, and pesticide screening
  • Premium Active Forms: Calcium ascorbate (non-acidic vitamin C), mixed tocopherols (superior to alpha-tocopherol alone), standardized curcumin extract (20% curcuminoids), trans-resveratrol (99% purity), BioPerine (95% piperine)
  • Clinical Dosing: Each nutrient dosed at therapeutic levels validated in peer-reviewed research—Vitamin C 250mg, Vitamin E 70mg, Nicotinamide 125mg, Curcumin 100mg, Resveratrol 150mg, BioPerine 15mg
  • Safety Profile: All ingredients have established safety records at recommended doses. Generally well-tolerated. Consult physician if pregnant, nursing, taking medications (especially anticoagulants), or have medical conditions.

Medical Disclaimer: The Antioxidant Essentials Bundle is a nutritional supplement system and is not intended to diagnose, treat, cure, or prevent any disease. These products are listed with the Australian Therapeutic Goods Administration (TGA) as complementary medicines under AUST L 521487 and AUST L 520796. While the individual ingredients are supported by peer-reviewed research demonstrating antioxidant and cellular protection benefits, individual results may vary. This information is for educational purposes and should not replace professional medical advice.

Consult your healthcare provider before starting this supplement regimen, particularly if you have existing health conditions, take prescription medications (especially anticoagulants or blood thinners), are pregnant or nursing, or have any chronic conditions. Curcumin and resveratrol may have mild blood-thinning effects. Vitamin C and E supplementation should be discussed with healthcare providers for those with specific medical conditions. Lifestyle factors including antioxidant-rich nutrition, regular exercise, stress management, and adequate sleep remain essential for optimal cellular health. Keep all supplements out of reach of children. Store in a cool, dry place away from direct sunlight.

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