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CardioProtect Bundle | Medical-Grade Cardiovascular Support | Zenutri Australia
TGA-Approved • Clinically Validated • Australian Made

CardioProtect Bundle

Three-Formula Cardiovascular Support System

3 Synergistic Formulas
150mg CoQ10 UbiQ Forte
100% Evidence-Based
CoQ10 • Magnesium + ALA • Vitamin D3/K2

Australia's most comprehensive cardiovascular protection system combining three TGA-approved, research-backed supplements in precisely calibrated therapeutic doses. The CardioProtect Bundle delivers targeted support for cardiac function, arterial health, blood pressure optimization, and mitochondrial energy production through advanced nutritional biochemistry.

Cardiovascular Synergy Mechanisms

CoQ10 + Magnesium: Mitochondrial Energy & Vascular Function

Dual support for cardiac ATP production and blood pressure optimization

Coenzyme Q10 (ubidecarenone) serves as an essential electron carrier in the mitochondrial respiratory chain, directly supporting cardiac ATP synthesis—the heart muscle requires enormous energy to maintain continuous contractile function. Magnesium bisglycinate acts as a cofactor for over 300 enzymatic reactions including ATP synthesis, calcium channel regulation, and endothelial nitric oxide synthase (eNOS) activity. Together, they enhance both cellular energy production and vascular smooth muscle relaxation, providing comprehensive cardiovascular support at the cellular level.

Vitamin D3 + K2: Calcium Homeostasis & Arterial Protection

Precision regulation preventing arterial calcification while supporting bone health

Cholecalciferol (D3) upregulates intestinal calcium absorption and bone matrix proteins, while menaquinone-7 (K2-MK7) activates matrix Gla protein (MGP) and osteocalcin—proteins essential for directing calcium to bone tissue and preventing ectopic calcification in arterial walls. This synergy is critical for maintaining arterial elasticity and cardiovascular health. Vitamin K2 deficiency is associated with increased coronary artery calcification—a major predictor of cardiovascular events—while adequate K2 intake has been shown to reduce this risk by over 50% in epidemiological studies.

Magnesium + Alpha-Lipoic Acid: Endothelial & Antioxidant Defense

Dual mechanisms supporting vascular health and oxidative stress protection

Alpha-lipoic acid (ALA) functions as both a lipophilic and hydrophilic antioxidant, uniquely capable of regenerating vitamins C and E while improving endothelial nitric oxide bioavailability—a critical factor in vascular health. Magnesium enhances ALA's effectiveness by supporting eNOS activity, reducing oxidative stress, and promoting vasodilation. Together, they provide comprehensive protection against endothelial dysfunction, the key initiating factor in atherosclerosis and cardiovascular disease progression.

CoQ10 + Vitamin D3: Synergistic Cardiovascular Protection

Combined mechanisms supporting cardiac function and immune-metabolic health

Both CoQ10 and vitamin D3 independently support cardiovascular function through distinct mechanisms—CoQ10 via mitochondrial energy production and antioxidant activity, D3 through calcium homeostasis, immune modulation, and direct cardiovascular tissue effects. Vitamin D deficiency impairs CoQ10 synthesis, while CoQ10 supports vitamin D receptor function. This bidirectional relationship enhances overall cardiovascular protection, particularly in aging populations where both nutrients commonly decline.

Magnesium + Vitamin D3: Enhanced Activation & Utilization

Critical cofactor relationship for vitamin D metabolism and function

Magnesium is essential for converting vitamin D into its active form (1,25-dihydroxyvitamin D3) through enzymatic hydroxylation in the kidneys and liver. It also regulates vitamin D binding protein and vitamin D receptor function. Without adequate magnesium, vitamin D effectiveness can be reduced by up to 60%, and vitamin D supplementation without magnesium can actually deplete magnesium stores, potentially worsening cardiovascular outcomes. This formula provides optimal magnesium to ensure vitamin D3 activation and utilization.

Comprehensive Cardiovascular Protection

Mitochondrial Energy Enhancement
150mg CoQ10 directly supports cardiac mitochondrial ATP production, essential for maintaining contractile force in the energy-demanding myocardium
Blood Pressure Optimization
Magnesium bisglycinate (55mg elemental) and alpha-lipoic acid (150mg) work synergistically to promote vasodilation and endothelial nitric oxide production
Arterial Health & Elasticity
180mcg Vitamin K2-MK7 prevents arterial calcification while 25mcg D3 ensures optimal calcium absorption—protecting cardiovascular flexibility
Antioxidant Defense System
Alpha-lipoic acid and CoQ10 provide comprehensive protection against oxidative stress, lipid peroxidation, and endothelial damage
Calcium Metabolism
D3/K2 synergy optimizes calcium distribution—enhancing bone density while preventing harmful arterial calcification
Endothelial Function
Multiple mechanisms support healthy endothelium—the critical interface between blood and vessel walls that regulates vascular health
Clinical Evidence & Research Foundation

The Science Behind CardioProtect

Every ingredient is supported by peer-reviewed research and clinical trials demonstrating cardiovascular benefits

Coenzyme Q10: Cardiac Function & Heart Failure
The landmark Q-SYMBIO trial demonstrated that CoQ10 supplementation (100mg twice daily) in heart failure patients reduced cardiovascular mortality by 43% and decreased hospitalizations. CoQ10 improves left ventricular ejection fraction, enhances exercise capacity, and reduces oxidative stress in cardiac tissue. Depletion is common with statin therapy and aging, making supplementation particularly relevant for cardiovascular risk reduction. Our 150mg dose provides therapeutic levels validated in clinical research.
Mortensen et al., JACC Heart Failure 2014 (Q-SYMBIO, PMID: 25282031) | Sharma et al., Circulation Heart Failure 2016 | Fotino et al., Front Biosci 2013
Magnesium: Blood Pressure & Vascular Function
Meta-analyses of randomized controlled trials confirm that magnesium supplementation produces dose-dependent reductions in both systolic (-4.18 mmHg) and diastolic (-2.27 mmHg) blood pressure. Magnesium acts as a natural calcium channel blocker, promotes endothelial nitric oxide production, and reduces vascular resistance. Our chelated bisglycinate form offers superior bioavailability compared to oxide or citrate forms. Magnesium deficiency affects over 50% of adults and is associated with increased cardiovascular mortality.
Zhang et al., Hypertension 2016 (PMID: 27402922) | Rosanoff et al., Nutrients 2021 | Fang et al., Am J Clin Nutr 2016 | Costello et al., Nutrients 2016
Vitamin D3 & K2: Arterial Calcification Prevention
The Rotterdam Study demonstrated that higher vitamin K2 intake reduced coronary calcification by 52% and cardiovascular mortality by 57% over 7-10 years. K2 (menaquinone-7) activates matrix Gla-protein (MGP), which inhibits vascular calcification—a key predictor of cardiovascular events. Combined with vitamin D3 (which increases calcium absorption), this synergy optimizes calcium metabolism, directing it to bones while preventing arterial deposition. Our 180mcg K2-MK7 dose matches levels shown effective in clinical trials.
Geleijnse et al., J Nutr 2004 (Rotterdam Study, PMID: 15051869) | Knapen et al., Thromb Haemost 2015 | Theuwissen et al., Thromb Haemost 2012
Alpha-Lipoic Acid: Endothelial Function & Oxidative Stress
Alpha-lipoic acid improves endothelial function by increasing nitric oxide bioavailability and reducing oxidative stress. Clinical trials show ALA (300-600mg daily) improves flow-mediated dilation (FMD), reduces inflammatory markers (CRP, IL-6), and enhances insulin sensitivity. As both a lipophilic and hydrophilic antioxidant, ALA protects against lipid peroxidation in cell membranes while regenerating vitamins C and E. Our 150mg dose combined with magnesium provides synergistic vascular protection.
Heinisch et al., Atherosclerosis 2010 | Sola et al., Free Radic Biol Med 2005 | Ziegler et al., Diabetes Care 2011 | Shay et al., Nutr Rev 2009
Magnesium + Vitamin D: Critical Cofactor Relationship
Magnesium is required for all enzymes that metabolize vitamin D, including 25-hydroxylase and 1-alpha-hydroxylase which convert D3 to its active form. Clinical studies show that vitamin D supplementation without adequate magnesium may not effectively raise 25(OH)D levels and can actually worsen magnesium deficiency. Conversely, magnesium supplementation enhances vitamin D status. This formula provides optimal magnesium to ensure vitamin D3 activation—a critical interaction often overlooked in cardiovascular supplementation.
Uwitonze & Razzaque, J Am Osteopath Assoc 2018 | Deng et al., BMC Med 2013 | Dai et al., Am J Clin Pathol 2016
CoQ10 + Statins: Restoration of Depleted Levels
Statin medications inhibit HMG-CoA reductase, the same enzyme pathway that produces CoQ10, leading to 25-50% depletion of endogenous CoQ10. This depletion is implicated in statin-associated muscle symptoms and may limit cardiovascular benefits. Multiple studies demonstrate that CoQ10 supplementation (100-200mg daily) restores levels, reduces muscle symptoms, and may enhance cardiovascular outcomes in statin users. This makes CoQ10 supplementation particularly important for the millions of Australians on statin therapy.
Banach et al., Arch Med Sci 2015 | Qu et al., Med Sci Monit 2018 | Caso et al., Am J Cardiol 2007 | Littarru & Langsjoen, BioFactors 2007

The CardioProtect Formula

Three precision-dosed TGA-approved supplements delivering comprehensive cardiovascular protection

AUST L 520795

UbiQ Forte

Ubidecarenone (CoQ10)

150mg per capsule

Supports cardiac mitochondrial ATP synthesis, antioxidant defense, and cellular energy production

1 capsule daily with breakfast or largest meal

AUST L 520793

MagLipo Core

Magnesium Amino Acid Chelate

275mg (55mg elemental magnesium)

Alpha-Lipoic Acid

150mg per capsule

Blood pressure support, vascular relaxation, endothelial function, antioxidant protection

1 capsule daily with any meal

AUST L 520792

Osteo+Core

Cholecalciferol (Vitamin D3)

25mcg (1000 IU)

Menaquinone-7 (Vitamin K2)

180mcg per capsule

Calcium metabolism optimization, arterial elasticity, prevention of vascular calcification

1 capsule daily with fat-containing meal

Progressive Cardiovascular Benefits Timeline

Experience measurable improvements in cardiovascular health markers with consistent use

Weeks 1-4
Months 1-3
3+ Months
Early Phase: Cellular & Metabolic Adaptation (1-4 Weeks)
  • Enhanced Cellular Energy: Increased cardiac ATP production from CoQ10 supporting contractile force and overall vitality
  • Reduced Oxidative Stress: Antioxidant network (CoQ10, ALA) begins neutralizing free radicals and protecting against lipid peroxidation
  • Improved Exercise Tolerance: Better oxygen utilization and reduced fatigue during physical activity as mitochondrial function improves
  • Magnesium Repletion: Restoration of intracellular magnesium stores improving vascular tone and muscle function
  • Initial Vitamin D Normalization: Serum 25(OH)D levels begin to rise with daily supplementation
Intermediate Phase: Vascular & Metabolic Optimization (1-3 Months)
  • Blood Pressure Normalization: Measurable reductions (4-5 mmHg systolic, 2-3 mmHg diastolic) from magnesium-mediated vasodilation and NO enhancement
  • Improved Endothelial Function: Enhanced nitric oxide bioavailability and flow-mediated dilation (FMD) measurable via ultrasound
  • Reduced Inflammation: Decreases in oxidative stress markers and inflammatory cytokines
  • Enhanced Arterial Compliance: K2 activation of MGP begins preventing vascular calcification progression
  • Optimized Calcium Metabolism: D3/K2 synergy directing calcium to bones while protecting arterial walls
  • Cardiac Function Improvement: Enhanced left ventricular function in those with reduced ejection fraction
Long-Term Phase: Comprehensive Cardiovascular Protection (3+ Months)
  • Sustained Blood Pressure Control: Maintained optimal blood pressure through multiple vasodilatory and endothelial mechanisms
  • Arterial Health Preservation: Reduced arterial stiffness (pulse wave velocity) and maintained endothelial integrity
  • Calcium Homeostasis: Optimized calcium distribution—enhanced bone density measured via DEXA, reduced arterial calcification via CT calcium scoring
  • Mitochondrial Resilience: Protected cardiac mitochondrial function supporting long-term contractile capacity and energy production
  • Cardiovascular Risk Reduction: Multi-factorial protection against atherosclerosis progression, thrombosis, and cardiac dysfunction
  • Metabolic Health: Improved insulin sensitivity and glucose metabolism from ALA and magnesium
  • Reduced Cardiovascular Events: Long-term supplementation associated with reduced major adverse cardiovascular events (MACE) in clinical studies

Clinical Usage Protocol

Evidence-based dosing schedule for maximum cardiovascular benefit

1

Morning: Energy Foundation

UbiQ Forte (CoQ10 150mg): Take 1 capsule with breakfast containing healthy fats. CoQ10 is lipophilic and absorption increases 3-fold when taken with dietary fat (olive oil, avocado, nuts, eggs).

Timing rationale: Morning dosing supports daytime cardiac energy demands and exercise capacity.

2

Morning/Anytime: Calcium Optimization

Osteo+Core (D3/K2): Take 1 capsule with a fat-containing meal (vitamin D and K2 are both fat-soluble). Can be taken with same breakfast as CoQ10.

Timing rationale: Vitamin D3 supports daytime calcium metabolism and immune function. K2 has a long half-life allowing once-daily dosing.

3

Flexible: Vascular Support

MagLipo Core (Mag + ALA): Take 1 capsule with any meal. Some prefer evening dosing as magnesium can promote relaxation.

Timing rationale: ALA has a 2-4 hour half-life but once-daily dosing at 150mg is clinically effective. Magnesium bisglycinate is well-tolerated at any time.

Optimization Tips

  • Consistency is critical: Take at the same times daily to maintain stable blood levels and optimize cardiovascular benefits
  • With fat: Always take CoQ10 and D3/K2 with meals containing healthy fats (15-20g) for optimal absorption
  • Timeline: Allow 8-12 weeks for full cardiovascular benefits to manifest—patience yields results
  • If on statins: CoQ10 supplementation is particularly important as statins deplete endogenous CoQ10 by 25-50%
  • Monitoring: Consider tracking blood pressure, exercise tolerance, and energy levels to assess progress

Pharmaceutical-Grade Quality Standards

TGA Listed Medicines
cGMP Certified
Third-Party Verified
Australian Made

Rigorous Quality & Safety Protocols

  • TGA Listed Medicines: All three formulations are individually listed with the Therapeutic Goods Administration (AUST L 520792, 520793, 520795), meeting Australia's stringent pharmaceutical quality standards. Start date: 25/11/2025.
  • Current Good Manufacturing Practice: Produced in TGA-licensed cGMP facilities including BJP Laboratories, CGS Pharma, Complementary Medicines Group, Lavida Nutraceuticals, and Lipa Pharmaceuticals—all with validated manufacturing processes and full batch traceability
  • Independent Laboratory Testing: Third-party verification by accredited Australian laboratories (Australian Laboratory Services, Eurofins, Symbio Laboratories, etc.) confirms identity, purity, potency, and absence of contaminants including heavy metals, microbiological, and pesticides
  • Premium Bioavailable Forms: Magnesium amino acid chelate (superior absorption vs oxide/citrate), Vitamin K2-MK7 (longer half-life than MK-4), Cholecalciferol D3 (more effective than D2)
  • Clinical Dosing: Each nutrient dosed at therapeutic levels validated in peer-reviewed cardiovascular research—CoQ10 150mg, Magnesium 55mg elemental, D3 25mcg, K2 180mcg, ALA 150mg
  • Safety Profile: All ingredients have established safety records at recommended doses. Minimal drug interactions. Consult physician if taking warfarin (K2 may affect clotting), or if on multiple cardiovascular medications.

Medical Disclaimer: The CardioProtect Bundle is a nutritional supplement system and is not intended to diagnose, treat, cure, or prevent any disease. These products are listed with the Australian Therapeutic Goods Administration (TGA) as complementary medicines under AUST L 520792, AUST L 520793, and AUST L 520795. While the individual ingredients are supported by peer-reviewed research demonstrating cardiovascular benefits, individual results may vary. This information is for educational purposes and should not replace professional medical advice.

Consult your healthcare provider before starting this supplement regimen, particularly if you have existing cardiovascular conditions, take prescription medications (especially anticoagulants like warfarin, antihypertensives, or statins), are pregnant or nursing, or have any chronic health conditions. Vitamin K2 may interfere with warfarin therapy—medical supervision required. Regular cardiovascular monitoring and lifestyle factors (diet, exercise, stress management) remain essential for optimal heart health. Keep all supplements out of reach of children. Store in a cool, dry place away from direct sunlight.

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Experience the power of synergistic supplementation with Zenutri's exclusive bundle collection. Each bundle is meticulously formulated by supplement experts to address multiple physiological pathways simultaneously, providing comprehensive support that individual supplements simply cannot match. Every product is individually TGA-listed (AUST L), manufactured to pharmaceutical cGMP standards, and backed by clinical research—delivering professional-grade nutrition for serious health optimization.

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1

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2

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3

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Therapeutic nutrient levels validated by peer-reviewed research—not symbolic amounts or proprietary blends hiding underdosed ingredients

4

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Daily schedules optimized for nutrient absorption and physiological rhythms—morning neuroprotection, midday energy, evening recovery

5

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Methylated B-vitamins, ubiquinol CoQ10, nicotinamide riboside NAD+ precursors, chelated minerals—superior absorption over cheap alternatives

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From selection to sustained wellness—your journey simplified

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2

Receive Complete System

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3

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4

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Every Zenutri bundle meets the highest standards in Australian supplement manufacturing

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