Vitamin A (retinyl palmitate) 900mcg RE · Zinc glycinate 20mg (equiv. elemental Zinc) · Selenomethionine 100mcg (equiv. Selenium)

Provides the bundle's foundational skin micronutrient layer. Vitamin A (retinyl palmitate) is directly involved in skin cell differentiation, epithelial tissue maintenance, and mucous membrane integrity — regulating keratinocyte proliferation and supporting the structural organisation of both the epidermis and dermis. Zinc glycinate supports wound healing, cellular repair, and protein synthesis, and is a cofactor for collagen-stabilising enzymes. Selenomethionine is a cofactor for glutathione peroxidase, the primary antioxidant enzyme protecting skin cells from UV-induced and environmental oxidative stress. All three are delivered in their most bioavailable forms, providing the micronutrient infrastructure upon which the other three pathways depend.

Vitamin C 250mg (as calcium ascorbate) · Mixed tocopherols (low-alpha) 70mg · Nicotinamide (B3) 125mg

Provides the bundle's collagen synthesis and antioxidant layer. Vitamin C (as calcium ascorbate) is an indispensable cofactor for prolyl and lysyl hydroxylase enzymes that stabilise the triple-helix collagen structure, making it the rate-limiting nutrient in collagen synthesis — the protein responsible for skin firmness, elasticity, and wound repair. Vitamin C is also the body's primary water-soluble antioxidant, protecting skin cells from reactive oxygen species in aqueous environments. Mixed tocopherols (Vitamin E) protect cell membranes from lipid peroxidation in fat-soluble environments — particularly important in UV-exposed skin tissue — and are regenerated by Vitamin C forming a self-reinforcing antioxidant network. Nicotinamide contributes to cellular energy metabolism via NAD+ pathways and supports skin barrier function.

Nicotinamide Riboside Chloride 150mg · Magnesium amino acid chelate 275mg (equiv. 55mg elemental) · Resveratrol 75mg · BioPerine® piperine 7.32mg

Provides the bundle's cellular energy and NAD+ metabolism layer. Skin is a high-turnover organ requiring constant cellular energy for replication, repair, barrier maintenance, and melanin regulation. Nicotinamide Riboside (NR) is a clinically studied precursor to NAD+ — a coenzyme required for mitochondrial energy metabolism, DNA repair via PARP enzymes, and sirtuin-mediated cellular maintenance. NAD+ availability declines with age and UV exposure, impairing the skin's capacity for repair and renewal. Magnesium supports ATP-dependent enzymatic reactions across cellular metabolism. Resveratrol activates sirtuin signalling pathways and contributes antioxidant support in the cellular signalling environment. BioPerine® enhances systemic bioavailability of key ingredients.

Curcuma longa Rhizome Extract 20:1 100mg (equiv. 2g dry rhizome) · Resveratrol 150mg · Activated B vitamins (methylated forms) · BioPerine® piperine 14.64mg

Provides the bundle's inflammatory balance and deep antioxidant layer. Chronic low-grade systemic inflammation accelerates skin ageing, impairs barrier repair, and amplifies the effects of UV and environmental oxidative damage. Curcuma longa extract (20:1, equivalent to 2g dry rhizome) modulates NF-κB inflammatory signalling pathways and contributes broad antioxidant activity. Resveratrol (150mg) activates sirtuin pathways involved in cellular stress resistance and longevity-associated mechanisms relevant to skin cell maintenance. Activated B vitamins in methylated forms support energy metabolism and nervous system function. Standardised piperine significantly enhances curcumin bioavailability, addressing curcumin's otherwise poor systemic absorption. CurcuNova establishes the cellular environment in which the other three products operate most effectively.